IGURATIMOD ALLEVIATES MYOCARDIAL ISCHEMIA/REPERFUSION INJURY THROUGH INHIBITING INFLAMMATORY RESPONSE INDUCED BY CARDIAC FIBROBLAST PYROPTOSIS VIA COX2/NLRP3 SIGNALING PATHWAY

Background: NLRP3 inflammasome contributes a lot to sterile inflammatory response and pyroptosis in ischemia/reperfusion (I/R) injury.Cardiac fibroblasts (CFs) are regarded as semi-professional inflammatory cells and they exert an immunomodulatory role in heart.Iguratimod provides a protective role in several human diseases through exerting a power

High sugar intake has long been recognized as a potential environmental risk factor for increased incidence of many Foot Rest Extrusion Deck non-communicable diseases, including obesity, cardiovascular disease, metabolic syndrome, and type 2 diabetes (T2D).Dietary sugars are mainly hexoses, including glucose, fructose, sucrose and High Fructose Cor

Tackling complex environmental issues requires transdisciplinary solutions that cannot be achieved, unless we integrate scientific disciplines and communicate science directly with civil society actors, decision-makers, and stakeholders.Alexander von Humboldt offered an approach to integrate knowledge across disciplines aiming to broadly understand

Bantul regency is a one region from five regencies in Jogjakarta Province.There are 17 district in Bantul regency, which is Srandakan district n the south side and sedayu district in the north side and close to the border with Sleman regency.The biggest potential is an agricultural sector, tourism,and manufacturing industry that expected to reduce